Abstract : Chemotherapy-induced peripheral neuropathy (CIPN) is one of the side effects related to chemotherapy treatment. The incidence ranges between 30 and 70 %. The current study was conducted to identify the use and effectiveness of coping strategies and their association with QOL among patients with CIPN. A cross-sectional correlational design using a convenience sampling approach was used in the current study. A sample of 100 participants was used to produce the study’s surveys including demographical and clinical information, an Arabic version of the quality of life questionnaire - chemotherapy-induced peripheral neuropathy (QLQ-CIPN20) and Arabic version of Jalowiec Coping Scale (JCS). Findings showed that confrontive coping strategies were the most commonly used by the participants (Mean =24.45, SD = 2.10) and also the effective (Mean 24.62, SD = 1.69). Strong negative relationships were found between use of coping strategies and QLQ-CIPN20 (r = -0.76, p<0.001) and strong negative relationships were found between effectiveness of coping strategies and QLQ-CIPN20 (r = -0.73, p<0.001). Since there is no reliable treatment for CIPN, therapeutic interventions that reduce the impact of CIPN through increasing the use of coping strategies is highly recommended in the treatment plan