Abstract : <p>This study aimed to determine the correlation between Cycle Threshold (CT) value with severity of clinical symptoms in Corona Virus Disease 2019 (COVID-19) patients at the time of admission. A survey cross sectional study was conducted in two hospitals: Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital in Makassar, Indonesia, involved 270 subjects from May to July 2020. Medical records which met the study criteria were included in this study. CT value data was collected and compared among different clinical symptom severity. The correlation was analysed using SPSS version 25. The statistical tests used were Anova and Chi Square test. A multivariate analysis was conducted using multinomial logistic regression. The mean CT value was significantly lower in severe group and higher in mild group (p &lt; 0.05). We also found a significant correlation between gender, age, comorbidities, and radiological features with the severity of clinical symptom (each p &lt; 0.01) and proceed to the multivariate analysis. The variables which significantly related to severity of clinical symptom were the radiological features of pneumonia (p &lt; 0.001), comorbidities (p &lt; 0.01), and CT value (p &lt; 0.05). The CT value has significant negative correlation with the severity of clinical symptoms in COVID-19 patients at the time of admission. Adjusted by other variables, CT value still has a significant association with severity of COVID 19 symptom.</p>