Vol - 28, Issue - 05
About the Journal
[This article belongs to Volume - 28, Issue - 05]
International Medical Journal
Journal ID : IMJ-16-04-2021-833
Total View : 398

Abstract : Hepatitis B virus (HBV) infection is a serious health problem affecting nearly 400 million people worldwide, which can lead to liver fibrosis. Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) are part of a complete blood count. High MPV and PDW values have been observed in hepatitis B patients with severe liver fibrosis. This study aimed to determine the correlation between degree of liver fibrosis with MPV and PDW in chronic hepatitis B patients. MPV and PDW data were collected from medical records of naive hepatitis B patients who underwent transient elastography (FibroScan) examination at Wahidin Sudirohusodo Hospital Makassar from January 2018 - December 2020. Degree of liver fibrosis determined by FibroScan. The statistical tests used were Pearson's correlation and ANOVA. The results were considered significant if p-value <0.05. This study included 862 subjects consisting of 62.8% male with a mean age of 39.1 ± 13.1 years. The distribution of FibroScan results were 63.1% non-fibrosis, 20.4% significant fibrosis, and 15.5 severe fibrosis. The degree of liver fibrosis has a significant positive relationship with each MPV and PDW, the higher degree of liver fibrosis is in accordance with higher MPV and PDW (each p<0.001). The highest mean of MPV and PDW were found in severe fibrosis (9.2 fl and 13.5 fl). The degree of liver fibrosis has a significant positive relationship with each MPV and PDW in chronic hepatitis B patients.

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