Abstract : Aging is a complex process and make progressive loss of functional capacity of organ such as skin. Trans epidermal water loss represent changes in skin permeability which happen in aging. There is an imbalance of immune system in aging. It can cause condition called inflammaging. Proinflammatory cytokines such as IL-6 and TNF-α were elevated in skin aging. Purpose: This study aims to find correlation between TEWL and proinflammatory cytokines in non-aging and aging Methods: This research is an analytic observational study with cross sectional design. The IL-6 and TNF-α level was measured by using sandwich ELISA technique. TEWL was measured by Tewa meter. Results: The mean value of IL-6 and TNF-α in both non-aging and aging group showed no significantly difference. The TEWL in aging and non-aging group showed no statistically significant difference with and IL-6 and TNF-α. Conclusion: There was no significant relationship between TEWL and proinflammatory cytokines in non-aging and aging group.