Abstract : Salivary diagnostics boasts increased accessibility, accuracy and affordability as a diagnostic modality and is safer for patients and healthcare workers compared to pre-existing modalities. Progressive increase in LDH levels are seen to be positively related to the degree of cellular atypia and can be used as a screening tool in assessing the malignant potential of premalignant lesions. Whereas its positive relationship with histological differentiation can be used as a prognostic indicator in malignancies. To study the correlation between salivary Lactate dehydrogenase (LDH) in Head and neck cancer (HNC) with the histopathological grade. Patients who were biopsy proven to have head and neck cancers, were planned for appropriate surgery based on staging and histopathology. Their preoperative salivary LDH and post-operative salivary LDH was measured to look for any change in values to prove a correlation between malignancy and salivary LDH levels and was compared with the histological grade. The grade of differentiation directly corresponds to the salivary LDH levels, with a statistically significant p value=0.0008. Stage wise preoperative salivary LDH shows statistically significance with p-value= 0.013 along with a statistically significant fall post- operatively (p-value=0.018) and at 6 months (p-value=0.046). Poorer the differentiation higher the Salivary LDH levels. There is a possible prognostic role of salivary LDH in head and neck malignancies which needs to be considered as an alternative or adjunct to traditional biopsy.