Vol - 25, Issue - 11
About the Journal
[This article belongs to Volume - 25, Issue - 11]
International Medical Journal
Journal ID : IMJ-30-10-2020-645
Total View : 347

Abstract : Successful recovery of severe COVID-19 with cytokine storm with Plasma Convalescent Therapy or Extracorporeal blood purification, has been with or without methylprednisolone has been reported, but not in diabetes comorbid which in immunocompromised where cortisone is immunosuppressant. So cortisone for anti- inflammation drugs should be not recommended. This study builds the potential benefit and harm of corticosteroid in pandemic COVID-19. Systematic Review with Science Direct search engine using keywords of methylprednisolone and COVID-19 are used. Bayesian analysis and network support this study. Cytokine storm and anti- inflammation/ immunosuppressant and immunocompromised/ comorbid are used. Insulin Resistance Syndrome cases are included, and non is excluded. Pneumonia and DIC as the excess, ventilated patients are also included. Flowchart of 15 references supported the table, one table describe the references. Three Systematic Reviews, 4 case reports, 2 cohorts, 4 reviews, 2 observational with minimal 15,385 subjects. The use of corticosteroid as prevention, treatment, and rehabilitation at mild, medium, severe phases are recorded and analyzed. Cortisone is immunosuppressant stuff that should be used only in a hospitalized patient in critical severe cases in overwhelmed/ hyperinflammatory stage COVID-19 pts. but should be forbidden (not recommended is not enough) in comorbidities. Using cortisone in plant/OTC in this pandemic era should be socialized the danger in the public domain to combat the easy spread

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