Vol - 32, Issue - 02
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[This article belongs to Volume - 32, Issue - 02]
International Medical Journal
Journal ID : IMJ-10-04-2025-1750
Total View : 23
Title : CYCLORUTHENATED COMPLEXES IN CANCER THERAPHY

Abstract : Cancer therapy failure is mostly caused by metastases (the spread of cancer cells from where they formed to another place in the body) which in some cases is due to cancerous cells being resistant to therapy. This results in mutations in the genomic makeup of the cancerous cells. Cyloruthenium complexes have been implemented in cancer therapy to help overcome drug resistant cancerous cells and to reduce the toxicity effect of therapy on the host. Ruthenium arene PTA compounds such as RAPTA- C have since been discovered and are used in cancer therapy as they portrayed positive results, while other ruthenium complexes are still going through the clinical trial stage. Herein, this literature review explores the synthesis of cycloruthenated complexes, their role in cancer therapy and drug-resistant tumors.
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