Abstract : To determine the frequency of depression in patients with Chronic Kidney Diseases (CKD). Observational cross-sectional study. Nephrology outpatient clinics of the Faisal Hospital, Karachi, Pakistan from July to December 2021. A total of 251 CKD patients were included in this study. After taking written informed consent they were requested to fill the Siddiqui –Shah Depression Scale (SSDS), Urdu version questionnaire. Scoring of depression scale was done and participants were labeled as positive for depression according to score. Participants were also categorize as having mild, moderate and severe depression according to Siddiqui –Shah Depression Scale (SSDS). Out of 251 patients there were 127(50.6%) males and 124 (49.4%) females. Frequency of depression in CKD patients was observed in 163(64.9%). In those subjects who have depression 83(33.1%) have mild depression, 56 (22.3%) have moderate depression and 24(9.6%) have severe depression. Depression is frequently found in CKD patients. Most of them have mild depression. Early diagnosis and monitoring the presence of depressive symptoms should be part of the routine care in patients with CKD.