Vol - 28, Issue - 11
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[This article belongs to Volume - 28, Issue - 11]
International Medical Journal
Journal ID : IMJ-18-11-2021-1063
Total View : 419
Title : Diabetes Mellitus and Alzheimer's Disease - Common Molecular Genetics

Abstract : Diabetes Mellitus and Alzheimer’s disease are the most important challenges in public health. Long term suffering of type-2 diabetes brings the possible risk of Alzheimer disease for the patient. The features of both diseases are characterized through the cause of inflammation as well as insulin impairment. Insulin degrading enzyme, Matrix metalloproteinase-9 acts as one of the therapeutic targets for both the disease. GSK-3 plays a central role in an insulin signalling pathway that also helps in the therapeutic intervention of Diabetes Mellitus and Alzheimer disease. Understanding common underlying molecular mechanisms in Diabetes Mellitus and Alzheimer's disease could be very useful in terms of predicting patient outcome and also in terms of identifying therapeutic targets for both the diseases.
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