Abstract : In this retrospective study all dual malignancy cases over a period of four years were included. During this period, out of over 2000 cases of malignancies, only 5 cases with dual malignancies were encountered. In our study all the cancers were of synchronous type as both the tumors in each of the patients were discovered simultaneously. The commonest combination was squamous carcinoma of the cervix with endometrial adenocarcinoma, seen in two out of the five cases. Case 1 was Invasive Carcinoma (NOS) of breast with synchronous Chromophobe Renal Cell Carcinoma. Case 2 was Squamous Cell Carcinoma of Cervix with Endometrial Adenocarcinoma. Case 3 was Adenocarcinoma of Colon with Squamous Cell Carcinoma of Cervix. Case 4 was Squamous Cell Carcinoma of Cervix with Endometrial Adenocarcinoma. Case 5 was Urothelial carcinoma of the Bladder with a synchronous Adenocarcinoma of Prostate gland. Genetic susceptibility and carcinogenic effects of radio/chemotherapy have largely been proposed for the genesis of multiple primary cancers. In addition, the treatment used for the first malignancy can result in damage to specific regions of DNA with chromosome rearrangement or loss, responsible for tumorigenesis.