Abstract : Post Operative Sore Throat (POST) is one of the most common, yet overlooked complaints following endotracheal intubation. Significant discomfort can be experienced by patients undergoing the procedure. Many factors are contributory to the development of POST, and the incidence depends on the method chosen to manage the airway, highest being after intubation (45.4%), whereas it decreases with use of the Laryngeal Mask Airway (17.5%) and further decreases on use of face mask. There is a large variation in incidence, with various studies estimating it to be from 21% - 65%, with some studies showing an incidence up to 90%. Various pharmacological measures that have been tried to decrease POST include inhalation of beclamethasone, aspirin, ketamine and licorice gargles, intravenous steroids, magnesium lozenges/local spray with lidocaine, and nebulisation with ketamine. This current study was planned to test and compare the efficacy of Aspirin and Normal Saline gargles given 15 minutes before induction of anesthesia on reduction of post-operative sore throat caused by oral endotracheal intubation. A prospective, double, blind, randomised, comparative study was carried out on 56 cases for a period of 2 years. Candidates were divided into 2 groups of 28 patients each, Group A and Group N. Group A Received Aspirin 350mg dissolved in 30 ml distilled water. Group N received normal saline 30 ml. After analysing the results obtained, it was concluded that Pre-operative gargles with Aspirin 325 mg in 30 ml Normal Saline for 30 seconds is an easy, cheap, patient friendly and efficient way of reducing both the incidence and severity of Post-Operative Sore Throat (POST) following oral endotracheal intubation. There were no side effects observed and patients were able to comfortably follow instructions.