Abstract : Oral cancer is one of the most frequently occurring cancers worldwide. Treatment of oral cancer includes radiotherapy, chemotherapy and surgery depending on staging of the cancer. Treatment may have many difficulties resulting in impairment of quality of life both functionally and psychologically. Oral mucositis is one of the most common complications in patients with Head and Neck cancer receiving radiotherapy. It has a great impact on quality of life in terms of physical pain affecting the patient’s ability to eat, swallow and speak. This study was intended to evaluate the efficacy of mouth wash containing Turmeric Triphala & Honey in patients with oral cancer undergoing Radiotherapy for Head & Neck Cancers. The study population comprised of 30 patients with head & neck cancer scheduled for undergoing radiotherapy who were divided into two equal groups, Group A given ORO-T mouth wash Containing Turmeric Triphala & Honey along with glycerine) and Group-B given glycerine at 3rd week and at 5th week of radiotherapy. Patients were asked to swish 10 ml of ORO-T diluted with water in 1:3 ratios for 1minute and then instructed to spit it out. Glycerine was applied topically over the mucosa. Symptoms were recorded based on WHO Mucositis Assessment Scale and pain score was recorded using VAS scale. This study included 30 patients in which Group A included 15 patients had given mouthwash (ORO_T) containing turmeric, honey, triphala, and glycerin, and Group B had only glycerin. Symptoms of oral mucositis was analyzed between both groups using the who oral mucositis assessment scale at the 3rd week and 5th week At 3rd week the results were statistically not significant with a p-value of 0.17. At 5th-week in both groups the results were statistically significant with p-value of 0.05. The mean score for pain in the 3rd week in both groups was 5.93 and 5.80 respectively and the results were not statistically significant, with a p-value 0.60. The mean score for pain at the 5th week in both groups was 3.60 and 4.27 respectively and the result were statistically significant with a p-value of 0.05. Our study showed that ORO –T mouthwash was effective and safe than topical glycerine in the management of radiation induced mucositis.