Abstract : Among facial injuries mandible is the most commonly fractured bone. Parasymphysis is the most commonly fractured portion of mandible. The objective of the present study was to evaluate and determine the efficacy of 2D and 3D miniplates in treatment of anterior mandibular fractures. This randomized control clinical trial was carried out in the Department of Oral and Maxillofacial Surgery, Nishtar Institute of Dentistry, Multan. Before starting the study, permission was taken from the Ethical Committee of Nishtar Institute of Dentistry. All the patients meeting inclusion criteria were chosen from Outpatient Department of Oral and Maxillofacial Surgery, Nishtar Institute of Dentistry, Multan based on history, clinical examination and radiographs. Patients had been divided into two groups by using random number table i.e. group A with odd numbers and group B with even numbers. In-group A, conventional 2D miniplates and group B, 3D miniplates had been used for ORIF of anterior mandibular fractures. Infection, wound dehiscence, mobility and paresthesia would be assessed by clinical examination on the third postoperative day, after 2 weeks, 4 weeks, 8 weeks and at the end i.e. 3 months. When the effect of method of fixation was noted on the complications, it was found that method of fixation was significantly associated with the complications having p-value 0.0001. There were 70% complications rate in 2D fixation technique and 13.33% complications rate in 3D fixation technique. While the complication of mobility of fracture segments was not found in both techniques. The present study showed that efficacy of 3D miniplates was better than 2D miniplates in the anterior mandibular fractures