Abstract : Dry eye disorder is a disease mainly due to the tear insufficiency which results in eye discomfort and disturbances in vision. Dry eye also affects the ocular dimensions especially corneal thickness. Central corneal thickness (CCT) assessment plays an important role in refractive surgeries and in the preoperative assessment of other ocular surgeries. To assess the effect of Dry Eye Disease on Central Corneal thickness with age and gender matched controls. 104 subjects (52 cases and 52 controls) who attended SRM Medical College and Hospital ophthalmology OPD were included in the study. Dry eye disease was diagnosed with DEQS questionnaire, Slit lamp examination, TBUT and Schirmer’s test. Pachymetry was used for measuring the CCT of all subjects. Student‘t’ test was used to determine the significance of difference between two means. p values less than 0.05 were considered statistically significant. In our study, there were sixty female patients and forty-four male patients. The ratio of male to female was 1:1.3. The CCT among cases was very low (533.19 ± 30.05) compared to controls (569.27 ± 45.56) and this difference was statistically significant (p < 0.05). When sub grouped under gender, the difference in CCT among males between the two groups was statistically significant and it was highly significant among females. When the reduction in CCT among the cases were studied under different age groups, the subjects in the 41 – 60 years age group had a statistically highly significant difference in CCT between the two groups while it was also significant in other age groups. There is a significant decrease in CCT due to dry eye disease. Pachymetry for CCT estimation shall be included in the routine management of dry eye patients so that corneal thinning could be identified earlier and treated with artificial tears or other substitutes.