Abstract : Thallium is a highly toxic substance especially its salt compounds and thallium poisoning is a frequent medical condition in many world countries. Thallium causes wide spread systemic damage especially to the liver. In this study we aimed to evaluate the hepatoprotective effects of capparis spinosa fruit extract on liver damage caused by induced thallium poisoned rats. 36 white albino male and female rats were classified randomly into 3 groups 12 rats each. Group 1 normal (negative control), group 2 thallium (positive control) in which rats were given 10mg/ kg thallium only, and group 3 (capparis group) in which the rats were given 200mg/kg capparis spinosa fruit extract for 5 successive days before administration of thallium dose 10 mg/kg. Results has shown significant reduction of serum liver transaminases (AST and ALT) which were highly elevated due to thallium poisoning. Histopathological sections revealed reduced hepatocellular damage in comparison to thallium group