Vol - 28, Issue - 07
About the Journal
[This article belongs to Volume - 28, Issue - 07]
International Medical Journal
Journal ID : IMJ-10-08-2021-875
Total View : 454

Abstract : Oral submucous fibrosis [OSMF] is a potentially malignant disorder of oral cavity. The epidemiology of OSMF strongly suggests an individual susceptibility which could be cytokine based, especially as the initial feature of OSMF is chronic inflammation accompanied by chronic fibrosis. Cytokines can act as Prognostic tools for detecting malignant transformation of oral potentially malignant disorders. It has been evident that different cytokines are expressed by dysplastic cells, the most common of which include tumour necrosis factor alpha [TNF-α], IL-1, IL-6, and IL-8. To assess the Serum levels of IL- 1 beta, and IL-6 in oral submucous fibrosis patients. This study group comprised 75 individuals divided into 3 groups GROUP A with 25 and GROUP B with 25 OSMF individuals, GROUP C 25 healthy individuals as controls. Serum levels of IL-1β, IL-6 were measured using enzyme linked immunoassay kits in all the subjects. The present study showed a significant rise in serum levels of IL-1beta and IL-6 levels in OSMF patients in contrast to the control group with the significance of p-value [<0.05]. Proinflammatory cytokines IL-1β and IL-6 were elevated, might act as a diagnostic and prognostic marker in oral submucous fibrosis patients.

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