Abstract : Due to the fact that correct adoption of surgical approach in head and neck surgery is basically the ultimate goal of surgery, performing 2D and 3D modeling using MRI and CT scanning can lead to correct election of surgical approach and increase diagnosis. The purpose of this study was to use high-resolution CT scan and MRI slices to create 2D and 3D models of head and neck using 3D Slicer software in patients undergoing infratemporal and parapharyngeal tumors, and to compare the effect of 3D modeling. We also aimed to compare the effect of 3D versus 2D modeling in patients undergoing surgery and to evaluate the performance of experienced surgical staff in surgical procedure and tumor type diagnosis based on 3D model. The present case-series study was performed on 10 consecutive patients undergoing surgery for infratemporal and parapharyngeal tumors. A 3D-model consisting separate CT scans or MRI images of the head and neck areas was made. We used 3D Slicer software to reconstruct the anatomical atlas of the head and neck structure and specific tissues we want to extract from CT scans and MRI images. There was no significant difference between the type of tumor identified according to the surgeon's opinion for each patient before and after viewing the images. There was a significant difference before and after reviewing the reconstructed images of the patients according to the surgeons' viewpoints with regard to vascular and neural involvements. Examining the images effectively and significantly influences the choice of surgical approach independent to the experience of surgeons. The use of 2D and 3D modeling on imaging techniques is effective in choosing surgical approach of patients with infratemporal and parapharyngeal tumors