Abstract : For an objective and comprehensive assessment of all indicators of the quality of life of patients, the questionnaire “MOS SF-36 - Health Status Survey” was used. A specific questionnaire “Quality of life after myocardial infarction” - Quality of Life after Myocardial Infarction (QLMI) was also used. The total number of patients included in the study was 120, of whom 75 were men and 45 women, 62.5% and 37.5%, respectively. All patients were divided into three groups. The first group included 40 practical healthy patients. The second group is also represented by 40 patients who had myocardial infarction without complications, and the 3rd group included 40 patients who had myocardial infarction and who had complications. Indicators of the physical component of QL in patients with myocardial infarction in the second and third groups were reduced by a factor of 2-3 compared with the control group (1) and were significantly different in all indicators, especially in 1– Physical functioning by 60–75%, 2 - by role functioning by 30–55%, 3 by the intensity of pain by 33–73%, and 4 by the general state of health by 32.5– 52.5%. Indicators of quality of life, psychological component in patients undergoing myocardial infarction without complication and with complications, were significantly lower compared to practically healthy people in the following sequence: by vital activity by 32.5-45%, by role functioning, due to emotional state by 23, 9-57.3%, mental health by 32-44%, and social functioning by 20.5-62.5%. The results of the study showed that the indicators of the physical and psychological component of QL in patients after myocardial infarction, with and without complications, were 2-3 times lower than in the control group (p <0.05; p <0.01; p <0.001), indicating the effect of myocardial infarction on QOL