Abstract : The Coronavirus Disease (COVID-19) is a rapidly spreading viral disease alerted by the World Health Organization (WHO) as a Global Pandemic which has resulted in panic around the world. COVID-19 spreads through ‘human-to-human’ transmission in forms of close contact. The spread of the disease has affected most countries, including Malaysia. A brief chronological event provides an understanding of the first encounter of this pandemic into Malaysia. An extensive report on the enforcement protocol by the Government of Malaysia and Ministry of Health is shared in this article. University Malaya Medical Centre (UMMC) being the lead university hospital, documents its frontline experience. Thus, the aims of this article are to report incidence and demographic data of COVID-19 in Malaysia and secondly, to highlight measures taken in managing patients in a university hospital set up, University Malaya Medical Centre (UMMC)