Vol - 25, Issue - 1
About the Journal
[This article belongs to Volume - 25, Issue - 1]
International Medical Journal
Journal ID : IMJ-06-01-2020-125
Total View : 584

Abstract : Factor V is a major part of the coagulation system and maintains a balance in pro-coagulant and anticoagulant pathways. Any deficiency or mutation can lead to disequilibrium. Factor V deficiency presents with bleeding while Factor V Leiden leads to a hypercoagulable state. Factor V deficiency can be congenital or acquired. The clinical findings range from asymptomatic to life-threatening hemorrhage. Prothrombin time and Activated partial thromboplastin time are elevated. The management includes Fresh frozen plasma infusion. This is a case of a 14-years-old female presenting with menorrhagia and hemorrhagic ovarian cyst, diagnosed as congenital factor V deficiency after factor V assay. Initially, it was considered a platelet functional defect. As seen in the current report, it is observed that patients with factor V deficiency present early in life with mucocutaneous bleeding, so early diagnosis and prompt management plays an important role in order to avoid the severe symptoms in future

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