Abstract : <p>The oxidation effects of ionizing radiation are well established and fully understood. However, exposure to very low doses of widely used isotopes may result in minor and hidden oxidative stress in some forms of hemoglobin. This formation alteration regarding the legends of hemoglobin's stereochemical function may play a role in hemoglobin disfunction.  This study was conducted on thirty-two male rabbits (Orycytolagus cuniculus) subdivided into two groups: control and animals exposed to gallium-68 isotope at a similar dose commonly used in diagnostic protocols for humans. Blood samples were collected twice: one after two hours of injection and the other after twelve hours. A linear, four-mathematical-equations matrix based on the Lamber-Beer law was used to measure the concentration of different hemoglobin derivatives. Results revealed a significant elevation of methemoglobin, the oxidized form of hemoglobin, two hours after injection, but this effect is completely reversed after twelve hours. This concludes that even low doses of isotopes result in oxidation of hemoglobin that recovers shortly.</p>