Histiocytes in Diabetes Mellitus - Case Report and Review of literature focusing on possible histiocytic lesions of diabetes mellitus

Vol - 28, Issue - 08

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[This article belongs to Volume - 28, Issue - 08]

International Medical Journal

Journal ID : IMJ-30-08-2021-907

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Title : Histiocytes in Diabetes Mellitus - Case Report and Review of literature focusing on possible histiocytic lesions of diabetes mellitus

Abstract : Macrophages in diabetes mellitus exhibit certain altered inflammatory and immune functions that include reduced phagocytic capability towards micro-organisms. This could lead to accumulation of excessive dysfunctional macrophages at the diabetic cutaneous wound and also predispose to many macrophage associated lesions such as necrobiosis lipoidica, xanthogranuloma, malakoplakia and rosai-dorfman disease, some of them have a progressive clinical course and could mimic malignancy. Hence, it is important to diagnose them at an earlIer stage to administer proper treatment. In this article, we have discussed macrophage dysfunctions that occur in diabetes mellitus, presented a case of diabetic abscess that exhibited florid histiocytic reaction and described histiocytic lesions that are associated with diabetes mellitus.

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