Abstract : Pancreatic cancer is lethal malignancy it is a seventh leading cause of cancer death in the world. Pancreatic cancer affects patients in their late adult life with a peak in the sixth - eight decade of life with male predominance. Pancreatic adenocarcinoma is the most common exocrine tumour. Periampullary tumours are neoplasms that arise in this site can originate from the duodenum, distal common bile duct (CBD), or the structures of the ampullary complex. A retrospective study of 32 cases was conducted from July 2016 to September 2018 with the most common age of presentation in 50- 60years with Male predominance. Adenocarcinoma of the pancreas was the most common pancreatic lesion found followed by neuroendocrine, solid pseudo papillary and Mixed neuroendocrine tumours. IHC marker was done for confirmation of neuroendocrine tumours. Most of the periampullary neoplasms were found in the duodenum with ductal adenocarcinoma being most common. This study was carried out to determine the histopathological pattern of the pancreatic tumours in the various age group thorough histopathological evaluation and immunohistochemically studies along with clinical correlation will ease the burden of Pancreatic disease.