Abstract : Dysfunctional uterine bleeding is a major gynecologic hassle, with numerous remedy options. A good-sized percentage of these sufferers go through a hysterectomy. to analyze the hormonal milieu at the tissue degree, we semi-quantitatively assessed the estrogen and progesterone receptors in the endometrial samples of fifty DUB sufferers, by way of Immunohistochemistry. We observed a big boom (p < 0.001) within the concentration of both estrogen and progesterone receptors in patients with dysfunctional uterine bleeding, in comparison to the regular populace. We also mentioned a substantial growth inside the endometrial thickness (p < 0.001) of sufferers with easy endometrial hyperplasia. Our look at demonstrates the position of estrogen and progesterone receptors in the etiopathogenesis of dysfunctional uterine bleeding and within the alteration within the morphology of endometrium, consisting of easy endometrial hyperplasia. We suggest the usage of progesterone antagonists and selective progesterone receptor modulators within the remedy of patients with dysfunctional uterine bleeding, especially in people with endometrial hyperplasia, who convey the longtime danger of endometrial carcinoma with sustained endometrial estrogenic stimulation.