Abstract : Mucormycosis is an opportunistic, fulminating fungal infection of the sino-nasal region. It tends to affect people with immune suppression. The nasal septum is a rare site of the disease and few cases have been reported in the literature. This paper discusses the incidence of nasal septal perforation in mucormycosis patients, with the aim of outlining possible explanations and reviewing associated characteristics. This was a retrospective analysis. Patients diagnosed with mucormycosis were admitted in the mucor ward at Dr DY Patil Medical College. An aggressive treatment protocol was used, i.e. an intensive course of antifungal drugs and frequent debridement of dead tissue. Most patients are asymptomatic and estimated that approximately two thirds of people infected show no nasal complaints. The absence of symptoms is directly related to the size and location of the perforation of the nasal septum. Orbit and intracranial extension was the preceding sign in all instances. The progression of the perforation was not controlled by a full course of treatment. Often, patients come to the ENT complaining of wheezing and nasal crusting and discover they possess a septal perforation. The more subtle symptoms, such as discrete whistles caused by air turbulence, are related to small perforations. Mucormycosis of the nasal septum is an ominous sign. Although rare, the lesion is progressive in nature and barely controlled by treatment.