Abstract : The host defense mechanism consists of innate immunity that provides immediate protection against infection and adaptive immunity that develops more slowly, but provide more specific protection against infection. The first line of defense in the innate immunity performed by the skin and mucous epithelial barrier as well as by cells and natural antibiotics that are in the epithelium, which all serve to inhibit the entry of microbes. Toll-like receptors (TLRs) are homologous proteins on the membrane of antigen-presenting cells (APC), which serves as a functional receptor that activates leukocytes to triggers the innate immune response against pathogens. The interaction between the microbial host cells and micro-organisms occurs when certain molecules are recognized by TLRs in cells of the body, particularly in intestinal epithelial cells and immune cells. TLRs are the first line of defense against pathogens, which have an important role in innate immunity. TLR-4 receptors were first discovered in humans and can recognize lipopolysaccharide (LPS) of gram-negative bacteria. One of the types of gram-negative bacteria is bacterium Salmonella typhi