Abstract : A 52-year-old hypertensive patient was admitted to the Department of Neurology after an epileptic seizure with the loss of consciousness. An urgent CT scan was performed, which did not show features of an intracranial haemorrhage, but visualised an area of an increased density at the level of the left temporal lobe. A head MRI scan was performed for the further diagnosis, which showed a proliferative process in the left temporal lobe enhancing after the administration of an intravenous contrast medium. The lesion was 19x20x18mm in size. Surgical resection of the primary lesion was performed. Histopathological report revealed a grade IV glioblastoma multiforme. The patient was qualified for the chemotherapy and radiotherapy. Due to the continuous recurrence and progression of the disease, the patient received a series of the NanoTherm therapies. Further genetic testing showed a loss of the CDKN2A/B cyclins, hence the patient was started on the ribocyclib therapy. Patients with the glioblastoma multiforme (GBM) should undergo a follow-up MRI scans of the head for an observation of the surgical sow or to detect the recurrence.