Abstract : The relationship between nurses' job satisfaction and stress is well documented. However, there is a lack of studies about the relationship between job satisfaction, anxiety, and depression among nurses. The general purpose of this study was to identify the effect of job satisfaction on anxiety and depressive symptoms among critical care nurses. This was a cross-sectional study with a convenience sample of 220 critical care nurses from one hospital from three sectors, governmental, private, and teaching in Amman, Jordan. Job satisfaction, anxiety, and depressive symptoms were measured by self-reported questionnaires. The whole sample was ambivalently satisfied, and having mild anxiety symptoms, and moderate-severe depressive symptoms. Nurses who were working in the intensive care units were the least in their level of anxiety and depressive symptoms and highly satisfied compared to other groups. Nurses who were working in the governmental hospital had higher levels of depressive symptoms than nurses who were working in a private hospital, and they were less satisfied. Working in the intensive care units decreased anxiety symptoms by 0.18 score, and every score increased in job satisfaction, decreased anxiety symptoms by 0.19 score. Being married increased depressive symptoms by 0.26 score and working in governmental hospitals increased depressive symptoms by 0.19 score. Every score increased in job satisfaction, decreased depressive symptoms by 0.27 score. Job dissatisfaction increased levels of anxiety and depressive symptoms among nurses. This might increase rates of burn out and intention to leave workplace areas ending with shortage and impairment of quality of care. The implementation of different strategies to improve job satisfaction among critical care nurses is necessary