Abstract : Pressure ulcer (PU) is one of the most common health problems worldwide. Pressure ulcer is a painful but generally preventable complication, and its management is a nursing practice. Purposes: this study was aimed to assess the nurses’ level of knowledge about PU management, and to measure the effects of demographic characteristics and hospital departments. This study was aimed to assess the nurses’ level of knowledge about PU management, and to measure the effects of demographic characteristics and hospital departments. A descriptive cross-sectional used Pieper PU Knowledge (2010) survey has been accomplished by 347 nurses who were picked from critical units. Above half of the nurses in Jordan (53.6%) had low level of knowledge management. Training courses, hospital policy, using assessment scale have significant different effects on knowledge level. Nurses’ knowledge of PU management needs to be improved. Cultivating the knowledge will be contributing to decreasing the patient burden