Vol - 25, Issue - 6
About the Journal
[This article belongs to Volume - 25, Issue - 6]
International Medical Journal
Journal ID : IMJ-13-06-2020-502
Total View : 371

Abstract : To determine the age-related incidence and lymphocytic infiltration (both peri-tumoral & intra-tumoral) in biopsies of patients with follicular adenoma and papillary carcinoma thyroid. MATERIALS AND METHODS: A total number of 50 patients presenting with follicular adenoma and papillary thyroid carcinoma (PTC) were selected for the present study. RESULTS: Among n=25 cases of follicular adenoma (n=19), 76.0% were females and (n=6) 24.0% were males and a female to male ratio was 3.1: 1. While among n=25 cases of papillary carcinoma (n=18), 72.0% were females, and (n=7) 28.0% were males and a female to male ratio was 2.1:1. This shows a female predominance in both groups. The ages of patients were divided into three age groups; Group 1(G I, 10-34 years), Group 2 (G II, 35-59 years) & Group 3 (G III, 60-84 years). The frequency of follicular adenoma and papillary carcinoma was related to age groups by applying Fisher’s Exact Test. The statistical relation of follicular adenoma and papillary carcinoma with age was found to be significant (p= 0.046). This shows young age preponderance in follicular adenoma; while in papillary carcinoma; a greater number of cases was present in 60-84 age groups. All of the biopsy sections were examined thoroughly under the microscope to observe the lymphocytic infiltrate (both intra-tumoural and peri-tumoural) within the histological section. When this lymphocytic infiltrate was graded according to the density, it depicted a higher frequency of papillary carcinomas showing a marked degree of lymphocytic infiltrate while the majority of follicular adenomas showed a moderate degree of lymphocytic infiltrate. CONCLUSION: The majority of follicular adenomas showed a moderate degree of lymphocytic infiltrate. The density of peri-tumoral & intra-tumoral lymphocytic infiltrate varies with transition from benign to malignant tumour. It might be an independent prognostic factor if studied on a comparatively large sample size with follow up of the patients

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