Abstract : Generic medicines usage is obligated to be applied in all government healthcare facilities in Indonesia as it was re-enforced in the regulation by the Ministry of Health. The objective of this study was to assess beliefs and perceptions towards generic medicines among doctors in Yogyakarta. A cross sectional study was conducted using a validated custom questionnaire developed from previous similar studies. Medical doctors working in local hospitals and clinics were invited to involve in this study. All data were presented descriptively and analyzed by performing Chi-square test with p-values of <0.05 were considered to point out statistical significance. A total of 210 medical doctors succesfully participated in this study. Medical doctors believed that the price of generics medicines is lower than their brand name drugs (3.78 ± 0.97). They perceived that generic substitution will reduce illegal promotion practices from drug manufacturer companies (3.56 ± 0.78). Automatic substitution of original drugs by generics (i.e. by pharmacists) as a policy measure were supported by the participated doctors (3.45 ± 0.67). Medical doctors working in public hospital significantly showed a better score compared to another working site groups (p <0.001). Those with shorter working experience were more likely to have positive perception towards generics drugs (p <0.001). General medical doctors and those who work in rural area also demonstrated significantly better score than their specialist colleagues and those who work in urban area (p<0.001 for both variables). Generally, medical doctors’ perceptions towards generic medicines were positive. The results in this study indicate that several actions in order to maintain and develop more positive perceptions may be necessary. Further national initiative regulation and innovative interventions (i.e incentive plans for health care professionals, monitoring and evaluation plan for generics) are needed in order to support the rational use of generic medicines