Abstract : Ideally the compounding drug is made from pure active substances but in reality, the prescribed drug as an extemporaneous compounding is in a form of factory finished drug dosage form, which should be intended for adult then formulated and adjusted to the conditions of patients. The Food Drug Administration (FDA) is aware of quality problems of drugs prescribed; one of the problems is contamination. This study aims to determine the microbial contamination in the dosage of non-sterile semi-solid extemporaneous compounding prescribed in primary health care centers. This study was an experimental observation conducted on primary health care centers by taking the prescriptions of semi-solid dosage forms used as samples. Hydrocortison cream and Gentamycin by microbial testing used chosen media for 5 pathogenic microbes, namely Pseudomonas aeruginosa, Salmonella spp., Staphylococcus aureus, Escherichia coli and Candida albicans. Data analysis was carried out descriptively by comparing the results of the study with the requirements contained in United States Pharmacopeia (USP). Based on USP requirements, there were three semi-solid non-sterile dosage forms of extemporaneous compounding from primary health care centers A, B and D that have not meet the requirements because from the microbial test results it was found bacteria Pseudomonas aeruginosa and/or Staphylococcus aureus