Abstract : To estimate the prevalence of myositis and hepatitis in dengue positive patients and their association. This cross sectional study was carried in Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), wardha district of central India during the month of June over a period of 3 months. Total 50 serologically diagnosed cases of dengue(NS-1-antigen) fever were included in this study. Participants were divided in 2 groups on bases of Creatinine kinase levels. After detailed history and clinical examination, liver function test, renal function test, Creatinine kinase(CK), creatinine clearance was calculated and urine for myoglobin were sent. Patients were given standard line of management. Out of 50 cases, 25 cases had raised CK levels. And out of those 25 cases, 8 (30%) patients tested positive for myoglobin in urine, (p< 0.05). Presence of myoglobin in urine is an indicator of rhabdomyolysis [1], [2]. Eighty two percent cases had hepatitis with increased SGPT levels, (p<0.05). All patients who had myositis had hepatitis. Twenty-three patients (90%) of 25 patients had raised creatinine levels and decreased creatinine clearance indicating acute kidney injury. All patients with raised CK levels showed hepatitis and evidence of acute kidney injury. Dengue patient should be evaluated for hepatitis and Myositis. Myositis should be predicated early so that acute kidney injury can be prevented. Hepatitis and myositis invariably co-exist and all patient with transaminitis should be evaluated for acute kidney injury and myositis by evaluating CK levels.