Abstract : Patients wearing orthodontic appliances experience varying degrees of pain and discomfort during the course of orthodontic therapy. Pain is one of the main factors responsible for the rejection of orthodontic treatments. Pain control is, therefore, crucial for both patients and orthodontists. In this review, an attempt is made to summarize the information regarding pain associated with orthodontic treatment, and to address questions orthodontists and patients or their parents may ask from the clinical point of view. Also, current orthodontic pain management procedures are presented. Data collection was performed by three reviewers independently. Using evidence found in the literature, an understanding of the causes, as well as an overview of recent management procedures used in reducing orthodontic pain, is provided. During orthodontic treatment, pain prevention and management should be given priority because heightened uncertainty in patients and parents can create a negative impact of emotional and confidence levels on the patient-parent- orthodontists