Abstract : <p>This study aims at measuring medical students&#39; satisfaction with e-learning during COVID 19 pandemic at College of Medicine Jouf University (COM JU) and identify gender differences. A descriptive cross-sectional study was conducted at (COM-JU) during academic year 2019-2020, students from 1st-5th year participated in the study. Sample size calculated as 200 students. Valid and reliable questionnaire was developed and sent electronically. Piloting of the questionnaire to 20 participants. Frequency and percentage of satisfied and dissatisfied students were calculated. We used the chi- square test to determine the association of variables based on gender groups. Total 139 responses were received 92 males and 47 females participated in the study. 0.82 was calculated as Cronbach&#39;s alpha of the questionnaire. Most of the students 102 (73.38%) used mobile for e leaning. Students were satisfied with course overview and support 69.21% males and 56.71% females, content and instructional methods 72.63% male and 64.18% females, assessment 75.45% male sand 52.98% females, virtual learning environment 69.02% of males and 56.47% of female students were dissatisfied with it. Study concludes that Students were satisfied with online courses during the lock down situation. The tool is valid and reliable too to measure student&#39;s perception of e learning courses.</p>