Abstract : Skeletal anchorage devices were developed for absolute anchorage during orthodontic treatment. Miniscrew anchorage device had been used for this purpose. The aim of this study was to evaluate the degree of pain and discomfort experienced after miniscrew insertion with three different analgesics. Fifty-one orthodontic patients in a university clinic were recruited who required bilateral miniscrews for orthodontic anchorage. Under local anesthesia, each patientreceived two miniscrews in the maxillary buccal area (one side 1.6x8mm and the other side 1.6x10mm). Each patient was given a questionnaire that included a visual analog scale (VAS) to indicate pain anddiscomfort after implantationfor three days. The patients were split into three groups according to the analgesic used (Paracetomol, Etoricoxib, and Ibuprofen). The maximum intensity was after 2 hour of insertion and decrease gradually to nearly disappear at third day. Pain intensity did not significantly differ between right and lift sides, males and females and between short and long miniscrews. Patients who took paracetamol reported more pain intensity than those who took Ibuprofen and Etoricoxib. While patients who took Ibuprofen reported the least pain intensity during the first two days. Ibuprofen 200mg taken three times daily for two days is effective in reducing pain and discomfort after miniscrew insertion