Abstract : The current study assessed the effect of Photobiomodulation [PBM] in combination with either Calcium Hydroxide [Ca(OH)2] or Mineral Trioxide Aggregate [MTA] as dental pulp capping agents on dental pulp exposures of dogs’ teeth. Ninety six teeth in 6 healthy mature dogs were divided in random into two major study groups; group I where calcium hydroxide was used as a pulp capping and group II in which MTA was used. Each group was subsequently divided into two subgroups, group (A) with no PBM and group (B) with PBM. The subgroups were consequently divided according to the observation period following completion of pulp capping into 1week (1W), 8 weeks (8W), and 16 weeks (16W). The teeth were examined for histological inflammatory response as well as dentine bridge formation. With regards to inflammatory response at 1 week significantly less intense inflammation was observed in PBM Ca(OH)2 group and PBM MTA compared to the no PBM Ca(OH)2 group and no PBM MTA group for the same time period. As for dentin bridge formation PBM MTA groups showed thicker dentine bridge formation at 16 weeks than no PBM MTA group for the same time period. Under the conditions of this study, laser irradiation appeared to be a beneficial adjunct in dental pulp capping procedures in which MTA was the pulp capping material.