Abstract : Nasal septal perforation is a defect in any portion of the cartilaginous or bony septum in which no overlying mucoperichondrium present. Multiple causes can lead to septonasal perforation. Nowadays with increasing desire to septorhinoplasty, the affected cases of septal perforation have been increased. The present study aimed to describe our experience on surgical repairing nasal septal perforation by alloderm grafting procedure. Seven patients suffering nasal septal perforation were enrolled in this case series study and underwent alloderm insertion in close or open septoplasty approach. The patients were divided based on the perforation size to less and more than one centimeter. Of Seven patients followed-up, two patients with perforation sized less than 1cm cured completely and there were no mucopericonderial closure in larger defects. In two patients who underwent revision rhinoplasty, the overall outcome was satisfactory after improvement of ptosis and dorsum without improvement in septal perforation. Alloderm is an alternative option in repairing nasal septal perforations sized less than one centimeter, but it may not be applicable for larger deformities