Abstract : To assess the prevalence of academic stress and perceived self-esteem and to identify their associated risk factors among nursing students. A cross-sectional study in which 130 nursing students were selected by convenient sampling. Academic stress and perceived self-esteem were measured by using Academic Stress Scale and Rosenberg’s Self-Esteem Scale. Multiple logistic regression was used to assess the combined effect of various factors associated with academic stress and perceived self-esteem. Overall, 78.46% of nursing students experienced high academic stress and 23.50% had low perceived self-esteem. The highest level of academic stress was more common among second and third year students (AOR 0.35, P 0.04). Academic stress was less common among students who received family support (AOR 5.34, P 0.01) and those having family salary ≥8000 SAR (AOR 0.38, P 0.01). In contrast, perceived self-esteem was low among second and third year students (OR 0.43, P 0.02) and among students who did not received family support (AOR 2.46, P 0.03). It is recommended that academic advising and guidance unit in nursing college to provide psycho-educational interventions concerning academic stress management. These interventions would help make the students to be aware of their level of self-esteem