Abstract : <p>Managing perioperative pain is a challenge for the treating surgeon and anesthesiologist. Transdermal route of drug administration is a novel method to deliver drugs in a simple, non-invasive and compliant way. In this prospective, randomized, double blinded, comparative study, we intent to compare the preemptive use of transdermal Buprenorphine patches of 5 mg and 10 mg, for analgesia, post operatively in lower limb orthopedic surgeries under spinal anesthesia. The results obtained showed that the Numerical Rating scale (NRS) scores were on higher side at all periods of observation in the 5 mg group and this difference was statistically significant. The NRS scores during rest and on movement in the pre- operative period and the period just before surgery were slightly higher in 5 mg group but this difference was not statistically significant. But the 8 hours ,12 hours, 24 hours, 48-hour post-surgery NRS scores were higher in the 5 mg group and this difference was statistically significant (p&lt;0.05) during rest and on movement. The rescue analgesia required by the 5 mg group was also higher than the 10 mg group and was statistically significant. Hence the 10 mg patch was more effective than the 5 mg patch for postoperative analgesia.</p>