Abstract : Musculoskeletal disorders (MSD) are injuries or disorders of the muscles, nerves, tendons, joints, cartilage, and spinal discs. This study aimed to determine the prevalence of musculoskeletal disorders among university students in Ajman UAE and to assess the factors associated with such disorders. A cross-sectional study was conducted among medical university students using an online self-administered Nordic questionnaire. SPSS version 27 was used for analysis. The association between dependent and independent variables was assessed using the Chi-square test. Statistical significance was set at p<=0.05. The sample size of this research was a total of 1008 students. Of these, 978 students responded with issues with one of the listed sites. Most students had an issue with their neck-978 (97%) while the least had issues with ankle/feet-342(33.9%). The research concluded that the overall prevalence rate of MSDs among university students is high. Females have a greater rate due to their smaller body size and lower muscular tone as compared to males. The most common factors significantly associated with MSDs were found to be female gender, age >-24 years, from EMRO countries, students at the college of pharmacy and health sciences, being physically inactive, having irregular physical exercise, positive history of MSK problems, history of trauma and accident, and chronic diseases, in the study.