Abstract : Complementary and alternative medicine (CAM) is defined as practice and products that can be used as alternative and part of conventional medicine. This study was conducted to identify the types of CAM that are used by Jordanian cancer patients, identify the factors associated with using CAM among Jordanian cancer patients and measure Health-related Quality of Life (HRQOL) among Jordanian cancer patients using CAM. A quantitative, cross-sectional design with convenience sampling approach was used. 201 participants completed the study survey with response rate 92 %. Majority of the participants used CAM during their illness period (145, 72.2%). The results from the current study showed that the majority of the participants used diet and nutritional supplements to minimize the side effects of traditional chemotherapy treatments (140, 69.6%), followed by to control disease, to decrease psychological pressure and distress and because of dissatisfaction with the conventional medicine (40: 19.9%, 12: 5.9%, 8: 3.9% and 1: 0.05% respectively). The results indicated that the participants had moderate level of QOL and the total of the QOL score mean was 82.72 (SD 11.29). Continuous education about type and actions of CAM is recommended for healthcare workers