Abstract : End-stage renal disease (ESRD) is a major public health problem worldwide and lead to extensive epidemiological research in the adult population, including Indonesia. Socio-demographic and clinical factors played an important role for dialysis patient in health-related quality of life (HRQOL). The objective of this study was to investigate the relationship of HRQOL to socio-demographic variables (gen¬der, age, education, and working status) as well as clinical vari¬ables (dialysis duration and comorbidities) in end-stage renal disease patients (ESRD) using EQ-5D measurement. A cross-sectional survey was conducted from June to October 2019. The questionnaire used a validated Indonesian version EQ-5D-5L. The EQ-5D includes a 5-item descriptive system to calculate the EQ-5D index score to determine the health status. Data were analyzed descriptively, and association between factors and HRQOL were analyzed using the Kruskal-Wallis test. The variables are statistically significant with p<0.05. Among 132 respondents, mostly female (56.82%) with higher participants were in 30-45years group and 49.24% were less than senior high school. The reported HRQOL as measured by mean EQ-5D-5L index value showed lower score in pain/discomfort and anxiety/depression dimensions. The results of univariate analysis showed a significant association between HRQOL with gender, age, education, and working status. The study provides a set of utility in patients and significant factors associated with QOL so that the significant interventions which can be developed by the health professionals to support end-stage renal disease patients