Vol - 28, Issue - 08
About the Journal
[This article belongs to Volume - 28, Issue - 08]
International Medical Journal
Journal ID : IMJ-09-09-2021-926
Total View : 383

Abstract : It is important to reduce amount of bleeding during lower segment caesarean section so as to reduce maternal morbidity due to bleeding. To control bleeding after CS, some medications such as oxytocin, prostaglandins (E1, E2, and F2α), and methylergonovine have been used. Treatment of PPH relies primarily on uterotonics, but early use of tranexamic acid (TXA) has become part of several recommended algorithms. However, the role of IV tranexamic acid has not been effectively evaluated in reducing blood loss during caesarean section, hence the need for this study. Patients with singleton pregnancy and gestational age ≥ 35 weeks were included in the study. Women were randomized into 2 groups- Group I and Group II, for two arm study with 75 subjects in each group. Preoperative haemoglobin was estimated in both the groups. 1-gram dose was chosen for this study. Tranexemic acid was not given to Group 1 while Group 2 were given TXA injection prepared by diluting 1 gram (10ml) TXA in 100ml of normal saline. At the end of the study, the collected data was analyzed. TXA was found to effective in reducing blood loss in study group. Mean blood loss in present study was 529.77 ml in control group and 411.05 ml in TXA group with p value of <0.05. Mean percentage fall in haemoglobin (gm/dl) in control group was 12.19 ± 3.64 which was significantly higher as compared to TXA group (8.93 ± 4.25) with p value of <0.0001. Tranexamic acid was found to be safe and effective in reducing blood loss after LSCS. In the present study, there was less drop in haemoglobin and haematocrit in tranexamic acid group. Tranexamic acid was not associated with any severe adverse drug reactions like thrombosis and hence it can be safely used for prevention of PPH. It was concluded that Tranexamic acid, plays a beneficial role in preventing PPH and maternal mortality.

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