Abstract : Rotavirus, a member of the reovirus circle of relatives, which lead to watery diarrhoea, vomiting and extreme dehydration in young children, rotavirus is commonplace, accounting for 35–60% of acute severe diarrhoea in youngsters below five years of age in international locations without rotavirus vaccine, with the highest attributable percentage in toddlers 1,2. Rotavirus diarrhoea is ubiquitous and, unlike bacterial diarrhoea, is not more usual in settings with terrible water, sanitation and hygiene. Rotavirus has a case-fatality price (CFR) of approximately 2.5% amongst kids in growing nations who gift to health facilities 3. Several rotavirus vaccines are certified and commercially available, all of them have been efficacious in randomized controlled trials in high- and low-profits settings. Two oral rotavirus vaccines are advertised in the world: the monovalent (RV1) Rotarix® and the pentavalent (RV5) RotaTeq®