Abstract : Secondary bacterial infections cause severe clinical outcomes, complicated diagnosis, sophisticated management, or death among patients with respiratory infections. The highest prevalence of bacterial infections secondary to coronavirus disease-19 (COVID-19) was reported among hospitalized immune suppressed patients who were exposed to central lines and mechanical ventilators. The secondary infection is usually caused by a single microbe or more with varying severity. In addition, if the secondary infection was caused by multi drug resistant bacteria, this will create additional crisis in treatment of critically ill COVID-19 patients. Understanding the synergy between COVID-19 and bacterial pathogens will have a great role in disease management. The aim of this review is to track and summarize bacterial co-infections among COVID-19 patients and their prevalence which may help provide answers for their relationship.