Abstract : Hepatic encephalopathy (HE) is a complex neuropsychiatric status characterized by loss of hepatocyte function. The pathogenesis of hepatic encephalopathy is still unknown. Characterized by increased blood ammonia directly act as a neurotoxin in advanced liver disease. Alterations of brain metabolites, cerebral blood flow and release of more inflammatory cytokines directly infect brain tissue. The incidence, prevalence, and mortality rate are increased due to HE. The study aims to assess the laboratory and clinical features of chronic alcoholic patients compared with stages of hepatic encephalopathy. A total of 62 alcoholic patients were included in this study. We have recruited chronic alcoholic patients more than 18 years of age who were diagnosed based on clinical features of alcoholic liver cirrhosis (MELD scoring method). The mental status was assessed by using West Haven Criteria for grading mental status. The quantity of consumption of alcohol was 116.59±45.60 and 110.00±62.45 in the case of the middle and upper classes respectively. The ammonia levels were shown 37.11±3.14 and 93.20±7.02 in stage-0 and stage-4 of HE respectively. In the case of stage-4, we can observe the increased ammonia levels compared to stage-0 of HE. Furthermore in the case of alcoholic liver cirrhosis, ammonia levels are positively related to HE and Child-Pugh grade.