Abstract : Surgical stress is an immediate aftermath of most surgical procedures which may directly/indirectly prolong recuperation and healing process of the animal. More stress response also emanates from the type of suture material and pattern used for the incision closure. Researchers are looking for materials that can lessen this stress. Serum cortisol measurement is one of the reliable markers of stress response. With the introduction of medical grade cyanoacrylate into clinical practice as a skin closure material, a number of promising outcomes have been reported by some researchers and its potential alternative to conventional sutures. This study evaluates surgical stress response in skin incisions closed with N-butyl Cyanoacrylate and Nylon while monitoring serum cortisol levels in Sahel bucks. Ten clinically healthy bucks (male goats) with mean age of 9.7±1.33 months with mean weight 13.2±1.31kg were randomly separated into two groups (A and B) of five bucks each. The bucks were prepared for surgery and skin incisions made were closed using N-butyl Cyanoacrylate and Nylon for group A and B respectively. Blood samples were taken before and after the procedure at 0, 5, 8, 24, 48 and 72 hours where serum cortisol levels were quantitatively evaluated. Serum cortisol levels were seen to rise in incisions closed with Nylon compared to those closed with N-butyl Cyanoacrylate.