Vol - 25, Issue - 8
About the Journal
[This article belongs to Volume - 25, Issue - 8]
International Medical Journal
Journal ID : IMJ-05-08-2020-558
Total View : 398

Abstract : Uric acid is the final oxidation product of purine catabolism. It was being reported by recent literature that serum uric acid levels are associated with insulin resistance and is consider an important risk factor in the development of glucose intolerance, obesity, and metabolic syndrome. It has also been suggested that higher serum uric acid levels might be associated with development of gestational diabetes mellitus, and insulin resistance during pregnancy. Gestational diabetes is defined as glucose intolerance that is not present or recognized prior pregnancy and developed when the placenta produce hormone that interferes with action of insulin; however, it is diagnosed by performing Oral glucose tolerance test. The aim of the study was to find the association between second trimester uric acid level and development of gestational diabetes mellitus. The present study is an observational pilot study conducted at Thumbay Hospital, Ajman, over a period of six months. A total of thirty-three women between 13th-28th weeks of gestational age who attended the Obstetric department were included in this study. Serum uric acid estimation was done in women between 13th-28th weeks of gestation and they were subsequently screened for Gestational diabetes mellitus by Oral Glucose Tolerance Test (OGTT) with 75 gm glucose according to IADPSG criteria. Cut-off value (3.6mg\dL) was used for uric acid levels. 23 pregnant women had normal UA levels out of which 5 (constituting 21.7%) had abnormal FBG. Out of the 10 subjects with UA (>3.6 mg\dL), 2 (constituting 20%) of them where seen to have a high FBG. Moreover, pregnant women with normal UA, 8.7% had high 2-hour Plasma glucose and with UA (>3.6 mg\dL), 9% had high 2-hour plasma glucose. Though there was no statistically significant association found between uric acid and OGTT, a weak positive correlation was observed

Our Certificates
Certificates
Certificates
Certificates
Certificates
Certificates
Certificates
Certificates
Certificates
Certificates
Certificates
Certificates