Abstract : The prognosis of systemic lupus erythematosus (SLE) has greatly improved in recent years, resulting in an increased number of patients reporting musculoskeletal complications such as osteonecrosis of the femoral head. Total hip arthroplasty (THA) can be utilised to alleviate the pain associated with this; however postoperative outcomes in patients with SLE are uncertain. This article was a case report of 48 year old woman and a SLE patient who underwent a THA on the left hip. After the surgery, patient underwent immobilization with non weight-bearing and extension of the knee for three weeks. After six weeks, patient started physiotherapy to improve range of motion with passive and active movement. Patient evaluation revealed no pain and progressive recovery of muscular strength after four months and could be able to walk with walker. Total hip arthroplasty using contemporary techniques and current management protocols can provide reliable functional improvement in patients with osteonecrosis secondary to SLE